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Target intelligence / Profile preview
Monoamine Transporter (MAT)
- Target
- MAT
- Molecular classification
- Transporter, Solute Carrier Family 6 (SLC6)
01
Overview
Monoamine transporters (MATs) are integral membrane proteins responsible for the reuptake of monoamine neurotransmitters—dopamine, serotonin, and norepinephrine—from the synaptic cleft back into presynaptic neurons. This process is essential for terminating neurotransmitter signaling and maintaining neurotransmitter homeostasis in the central nervous system. They are critical targets for many drugs including antidepressants (SSRIs/SNRIs), psychostimulants like cocaine/amphetamine, as well as being implicated in neuropsychiatric disorders such as depression or ADHD.
- Other names
- Dopamine transporterSERTNETDATSerotonin transporterNorepinephrine transporter
02
Mechanism of action
Inhibition of monoamine reuptake
03
Biological functions
Neurotransmitter reuptakeRegulation of synaptic neurotransmitter concentrationTermination of neurotransmitter signalingNeurotransmitter homeostasis
04
Disease associations
DepressionADHDNeuropsychiatric disordersMental illnesses
05
Safety considerations
Potential for drug interactionsSide effects associated with altered monoamine levels
06
Interacting drugs
SSRIs
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