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Target intelligence / Profile preview
Monocarboxylate Transporter (MCT)
- Target
- MCT
- Molecular classification
- Transporter, Solute Carrier
01
Overview
Monocarboxylate transporters (MCTs) are a family of proton-linked plasma membrane transporters responsible for the translocation of monocarboxylates, such as lactate, pyruvate, and ketone bodies, across biological membranes. They play essential roles in cellular metabolism, pH regulation, and nutrient transport. Overexpression of certain MCT isoforms is observed in various cancers, making them potential therapeutic targets. Functional expression requires association with ancillary proteins like basigin or embigin.
- Other names
- Solute Carrier Family 16SLC16Lactate TransporterPyruvate TransporterKetone Body Transporter
02
Mechanism of action
Inhibition of monocarboxylate transport
03
Biological functions
Metabolic shuttlingpH regulationNutrient transportLactate transportPyruvate transportKetone body transport
04
Disease associations
CancerMetabolic disorders
05
Safety considerations
Off-target effects of inhibitorsPotential for metabolic disruption
06
Interacting drugs
MCT inhibitors
07
Biomarkers
MCT1 expression in tumorsMCT4 expression in tumors
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