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Monocarboxylate Transporter 1 (MCT1)
- Target
- MCT1
- Molecular classification
- Solute Carrier, Transporter, Monocarboxylate Transporter
01
Overview
Monocarboxylate transporter 1 (MCT1), encoded by the SLC16A1 gene, is a transmembrane protein responsible for the proton-linked transport of monocarboxylates such as lactate, pyruvate, and ketone bodies across cell membranes. It plays a crucial role in cellular metabolism, energy homeostasis, and various physiological processes, including the Cori cycle and the astrocyte-neuron lactate shuttle. MCT1 function is dependent on interaction with ancillary proteins, particularly basigin, for proper localization and activity. Overexpression of MCT1 has been implicated in certain cancers.
- Other names
- SLC16A1Solute Carrier Family 16 Member 1Monocarboxylase transporter
02
Mechanism of action
Proton-coupled symport of monocarboxylates
03
Biological functions
Proton-linked transport of monocarboxylatesLactate transportPyruvate transportKetone body transportShort-chain fatty acid transportCori cycleAstrocyte-neuron lactate shuttleEnergy metabolism
04
Disease associations
CancerMetabolic disorders
05
Interacting drugs
3-bromopyruvate
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