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Target intelligence / Profile preview
C-C motif chemokine 2 (CCL2)
- Target
- CCL2
- Molecular classification
- CC chemokines, Cytokine
01
Overview
C-C motif chemokine 2 (CCL2), also known as monocyte chemoattractant protein-1 (MCP-1) and small inducible cytokine A2, is a key member of the CC chemokine family involved in immune cell recruitment and inflammatory responses. It signals primarily through binding to its receptor CCR2, inducing strong chemotactic responses. Elevated levels of CCL2 are implicated in chronic inflammatory conditions and cancer progression, making it a potential therapeutic target.
- Other names
- Monocyte chemoattractant protein 1MCP-1Small inducible cytokine A2
02
Mechanism of action
Inhibition of CCL2 signaling prevents immune cell recruitment and reduces inflammation, angiogenesis, and tumor progression.
03
Biological functions
Immune cell recruitmentInflammatory responseMonocyte chemotaxisRegulation of cellular mechanicsAngiogenesisModulation of host immune response
04
Disease associations
Rheumatoid arthritisCancerProstate cancerRenal cell carcinomaLung cancerLeukemiaMultiple myelomaInflammatory disorders
05
Safety considerations
Potential for off-target effects on other chemokine pathwaysRisk of immunosuppressionUnintended consequences on immune surveillance of tumors
06
Biomarkers
CCL2 levels in plasma or serum
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