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Monocyte chemoattractant protein 3 (MCP‑3/CCL7)

Target: MCP‑3/CCL7
Molecular classification: CC Chemokine, Chemokine

Overview

Monocyte chemoattractant protein 3 (MCP‑3), also known as CCL7, is a chemokine belonging to the CC subfamily. It acts as a potent chemoattractant for multiple leukocyte types, including monocytes, eosinophils, basophils, dendritic cells, neutrophils, NK cells, and activated T lymphocytes. It plays important roles in normal homeostasis as well as pathologies such as cancer, autoimmune diseases, chronic inflammation, and infection.

Other names: Chemokine (C-C motif) ligand 7Monocyte-specific chemokine 3

Mechanism of action

Recruitment of leukocytes via CCR1, CCR2, and CCR3 receptor activation

Biological functions

ChemoattractionLeukocyte migrationImmune responseRegulation of macrophage functionNeutrophil migration

Disease associations

CancerAutoimmune diseasesChronic inflammationInfection

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