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Target intelligence / Profile preview
Monocyte Chemotactic Protein 1 (MCP-1)
- Target
- MCP-1
- Molecular classification
- Chemokine, CC chemokine family, Cytokine
01
Overview
Monocyte Chemoattractant Protein-1 (MCP-1), also known as CCL2, is a key chemokine involved in the recruitment of monocytes, macrophages, and other immune cells to sites of inflammation. It plays a significant role in various diseases characterized by chronic inflammation and tissue injury, including diabetes, atherosclerosis, and obesity-related complications. MCP-1 exerts its effects by binding to the CCR2 receptor, triggering intracellular signaling cascades that promote cell migration, proliferation, and cytokine release.
- Other names
- CCL2C-C motif chemokine ligand 2Small inducible cytokine A2Monocyte Chemotactic Activating Factor (MCAF)
02
Mechanism of action
Drugs targeting MCP-1 typically aim to block its interaction with CCR2, thereby inhibiting monocyte recruitment and downstream inflammatory signaling. Mechanisms may involve CCR2 antagonists or antibodies that neutralize MCP-1.
03
Biological functions
ChemotaxisImmune cell recruitmentInflammationCell migrationAngiogenesisCytokine release
04
Disease associations
Type I diabetesType II diabetesDiabetic nephropathyAtherosclerosisObesity-induced insulin resistanceNephropathyRetinopathyCardiovascular diseaseInflammation
05
Safety considerations
Blocking MCP-1 may impair normal immune surveillance and increase susceptibility to infection.Potential for off-target effects due to the involvement of chemokines in diverse biological processes.
06
Biomarkers
MCP-1 levels in serum or tissue can serve as a biomarker for inflammation and disease progression in conditions like diabetes, atherosclerosis, and kidney disease.
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