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Monocyte-Macrophage System (MPS)
- Target
- MPS
- Molecular classification
- Cellular System, Immune System Component
01
Overview
The monocyte-macrophage system, also known as the mononuclear phagocyte system, is a critical component of the innate immune system. It comprises circulating monocytes in the blood and tissue-resident macrophages throughout various organs. These cells are united by their ability to perform phagocytosis—engulfing and digesting pathogens, cellular debris, and apoptotic cells. They also present antigens to T lymphocytes, secrete cytokines, and play roles in tissue homeostasis and repair. Dysfunction within this system is implicated in numerous diseases, including immunodeficiencies, autoimmune/inflammatory diseases, and genetic disorders.
- Other names
- Mononuclear Phagocyte System
02
Mechanism of action
Not applicable
03
Biological functions
PhagocytosisAntigen presentationCytokine secretionTissue homeostasisTissue repairImmune regulationWound healingTissue remodelingAngiogenesisIron recycling
04
Disease associations
ImmunodeficiencyAutoimmune diseasesInflammatory diseasesLysosomal storage diseasesMonocytic leukemiaMalignant histiocytosisAnemiaInfection
05
Safety considerations
ImmunosuppressionExcessive inflammationDysregulated phagocytosis
06
Interacting drugs
Corticosteroids
07
Biomarkers
CD14CD16FcγRI/CD64CR3/CD11b/CD18
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