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Target intelligence / Profile preview
Monocytic leukemia zinc-finger protein-related factor (MORF)
- Target
- MORF
- Molecular classification
- Enzyme, Transcription coactivator, Histone modification enzyme, Lysine acetyltransferase
01
Overview
Monocytic leukemia zinc-finger protein-related factor (MORF), also known as KAT6B or MYST4, is a catalytic subunit of the major human lysine acetyltransferase (KAT) complex. It is essential for neurogenesis, transcriptional regulation, and chromatin remodeling. The protein possesses domains that bind to acetylated or acylated lysine residues on histone H3, thereby influencing gene expression by modifying chromatin structure. Mutations or translocations of MORF are implicated in various cancers and developmental disorders. MORF functions both as a "writer" (acetyltransferase) and "reader" (acyllysine recognition) of lysine acylation, critical for the formation of open chromatin domains and transcriptional control
- Other names
- KAT6BMYST4
02
Mechanism of action
Histone acetyltransferase activity, acetylation of lysine residues on histone H3, regulation of chromatin accessibility
03
Biological functions
Histone acetylationChromatin remodelingTranscriptional regulationNeurogenesis
04
Disease associations
CancerDevelopmental disorders
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