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Target intelligence / Profile preview
Monomethyl auristatin E (MMAE)
- Target
- MMAE
- Molecular classification
- Tubulin polymerization inhibitor, Antimitotic agent, Synthetic derivative
01
Overview
Monomethyl auristatin E acts by binding tubulin at the vinca site and preventing microtubule assembly. This mechanism underlies its use as a highly potent cytotoxic agent when delivered specifically into tumor cells via antibody-drug conjugates. Its effectiveness relies on precise targeting because free systemic administration would result in unacceptable toxicity due to widespread inhibition of cell division across normal tissues.
- Other names
- Auristatin E monomethyl etherMonomethyl auristatinVedotin (when part of an ADC)474645-27-7
02
Mechanism of action
Inhibition of tubulin polymerization, leading to mitotic arrest and apoptosis.
03
Biological functions
Inhibition of tubulin polymerizationMitotic arrestApoptosisCell cycle disruption
04
Disease associations
CancerLymphomaLeukemiaSolid tumors
05
Safety considerations
High toxicityLimited brain penetrationPotential for off-target effects if released systemically
06
Interacting drugs
Antibody-drug conjugates (ADCs)
1 more in the full profile.
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