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Target intelligence / Profile preview
Monomethyl Fumarate (MMF)
- Target
- MMF
- Molecular classification
- Small Molecule, Active Metabolite
01
Overview
Monomethyl fumarate (MMF) is a small molecule and the active metabolite of dimethyl fumarate (DMF), used as an oral therapy for relapsing forms of multiple sclerosis (MS). It activates the Nrf2 pathway, modulates NF-kB, interacts with glutathione, and may inhibit pyrimidine synthesis in lymphocytes. Common side effects include flushing, gastrointestinal symptoms, and lymphocyte count reduction, necessitating regular blood monitoring.
- Other names
- Methyl hydrogen fumarateFumaric acid monomethyl esterBafiertamFDA UNII: 45IUB1PX8R
02
Mechanism of action
Activates the Nrf2 pathway, modulates NF-kB, interacts with glutathione, and inhibits pyrimidine synthesis in lymphocytes.
03
Biological functions
Nrf2 Pathway ActivationNF-kB ModulationGlutathione InteractionImmunomodulation
04
Disease associations
Multiple Sclerosis
05
Safety considerations
FlushingGastrointestinal symptoms (nausea, diarrhea)Lymphocyte count reductionRisk of infection (PML)
06
Interacting drugs
Dimethyl Fumarate
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