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Target intelligence / Profile preview
Monophosphoryl lipid A
- Molecular classification
- Adjuvant, Toll-like receptor agonist, Lipid
01
Overview
Monophosphoryl lipid A (MPLA) is a detoxified derivative of the endotoxin lipopolysaccharide (LPS), specifically derived from the cell wall of *Salmonella enterica*. It acts as a Toll-like receptor 4 (TLR4) agonist, enhancing immune responses while minimizing inflammatory toxicity. MPLA is used as an adjuvant in several vaccines to improve efficacy and promote robust seroconversion by activating both MyD88-dependent and TRIF-dependent signaling pathways.
- Other names
- MPLADetoxified Lipid A
02
Mechanism of action
TLR4 agonist; activates MyD88-dependent and TRIF-dependent signaling pathways, leading to dendritic cell maturation, B cell activation, and Th1-biased immune responses.
03
Biological functions
Immune response modulationTLR4 activationAntigen presentation enhancementAdjuvant activity
04
Disease associations
Infectious diseaseCancer (immunotherapy)Vaccine development
05
Safety considerations
Potential for inflammation (lower than LPS)Adverse reactions to vaccines containing MPLA
06
Interacting drugs
Cervarix
2 more in the full profile.
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