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Target intelligence / Profile preview
TTK protein kinase (Mps1)
- Target
- Mps1
- Molecular classification
- Enzyme, Protein Kinase, Serine/threonine kinase, Tyrosine kinase, Dual Specificity Kinase
01
Overview
TTK protein kinase, also known as Monopolar Spindle 1 (Mps1) kinase, is a serine/threonine and tyrosine kinase crucial for regulating cell division and mitotic checkpoint signaling. It ensures accurate chromosome segregation and prevents premature progression from metaphase to anaphase. Dysregulation is implicated in various cancers, making it a therapeutic target. Inhibitors are under investigation for their anti-cancer properties by inducing cell death in rapidly dividing tumor cells.
- Other names
- Monopolar Spindle 1 kinasedual specificity protein kinase TTKCT96Esk1
02
Mechanism of action
Inhibition of TTK kinase activity
03
Biological functions
Cell cycleMitotic checkpoint signalingChromosome segregationKinetochore functionSpindle assembly checkpoint
04
Disease associations
CancerOvarian cancerGastric cancerOsteosarcomaPapillary thyroid cancer
05
Safety considerations
Potential for off-target effectsToxicity due to disruption of cell division in normal cells
06
Interacting drugs
Mps1/TTK inhibitors
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