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Target intelligence / Profile preview
Monopolar spindle protein kinase Mps1
- Molecular classification
- Enzyme, Protein Kinase, Dual-specificity serine/threonine and tyrosine protein kinase
01
Overview
Monopolar spindle protein kinase Mps1 (TTK) is a dual-specificity serine/threonine and tyrosine protein kinase that plays a crucial role in the spindle assembly checkpoint (SAC), ensuring accurate chromosome segregation during mitosis. It is essential for recruiting SAC proteins to unattached kinetochores and inhibiting the anaphase-promoting complex/cyclosome (APC/C). Overexpression of Mps1/TTK is observed in various cancers, correlating with tumor aggressiveness and poor prognosis, making it a promising anticancer drug target. Several small-molecule inhibitors have been developed, demonstrating antitumor activity.
- Other names
- TTK protein kinaseMonopolar spindle 1 kinase
02
Mechanism of action
Kinase inhibitor
03
Biological functions
Cell cycleSpindle assembly checkpointRegulation of mitosisChromosome segregation
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to kinase family similarityToxicity associated with cell cycle inhibition
06
Interacting drugs
AZ 3146
3 more in the full profile.
07
Biomarkers
Mps1/TTK expression levels
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