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Monounsaturated fatty acid metabolism pathway
- Molecular classification
- Other (biochemical/metabolic pathway)
01
Overview
The monounsaturated fatty acid metabolism pathway encompasses the synthesis and catabolism of monounsaturated fatty acids (MUFAs), such as oleic acid, typically mediated by enzymes including stearoyl-CoA desaturase (SCD), acetyl-CoA carboxylase (ACC), and elongases[4][6]. MUFAs are generated in the liver and other tissues via de novo lipogenesis and are incorporated into membrane phospholipids and triglycerides, impacting energy storage, membrane composition, and intracellular signaling[1][4]. This pathway interacts with hormonal regulation and plays roles in metabolic and cardiovascular diseases as well as immune regulation, with individual enzymes within the pathway representing more appropriate pharmacological targets than the pathway as a whole[4][5][6].
- Other names
- MUFA metabolismMonounsaturated fatty acid biosynthesis and degradationMonounsaturated lipid metabolism pathway
02
Mechanism of action
Enzyme inhibition (for SCD1, ACC, FASN): inhibition decreases the synthesis of monounsaturated fatty acids, which may affect lipid storage and cellular signaling
03
Biological functions
Lipid biosynthesisEnergy storage and releaseRegulation of membrane fluidityIntracellular signaling
04
Disease associations
Cardiovascular disease (as plasma MUFA/triglyceride levels are linked to risk factors)Metabolic syndrome (elevated MUFA synthesis involved in pathogenesis)Immune modulation (modification of interferon signaling and inflammatory responses)
05
Safety considerations
Altering overall fatty acid metabolism can cause metabolic disturbances, including fatty liverPossible effects on membrane fluidity and cell signalingImpact on immune response due to crosstalk with interferon and inflammation pathways
06
Biomarkers
Plasma monounsaturated fatty acid levels (e.g., oleic acid)SCD1 expression or activityTriglyceride concentrations
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