Mood regulation

Mood regulation describes the processes and pathways by which the central nervous system controls emotional state, involving complex interactions among neurotransmitters (such as serotonin, dopamine, norepinephrine, glutamate, and GABA), neuropeptides, hormones (e.g., cortisol via the HPA axis), neurotrophins (e.g., BDNF), and multiple brain regions (such as the prefrontal cortex, amygdala, and hippocampus)[1][2][3][4][5][6]. It is not a discrete molecular entity, receptor, or druggable target, but rather an umbrella term for a network of molecular, cellular, and anatomical systems influencing emotion and affect. Drugs used to alter mood (e.g., antidepressants, anxiolytics, antipsychotics) typically target individual components of these systems, not "mood regulation" as a single entity[1][2][6]. Thus, this is not an appropriate entry for molecular target-based databases or therapeutic targeting without specifying the actual molecular entities involved.