Target intelligence / Profile preview

Moraxella catarrhalis Surface Proteins (McSPs)

Target: McSPs
Molecular classification: Outer Membrane Protein (OMP), Autotransporter, TonB-dependent transporter, Surface Protein

Overview

Moraxella catarrhalis surface proteins (McSPs), particularly Ubiquitous Surface Proteins (UspAs) such as UspA1 and UspA2, are crucial for bacterial pathogenicity. They mediate adhesion to host cells, confer serum resistance by binding complement regulatory molecules like C4BP and C3/C3b, and facilitate iron acquisition. Their sequence diversity contributes to immune evasion and poses challenges for therapeutic targeting. Other proteins, like CopB, contribute to iron uptake. McSPs are considered therapeutic targets for preventing or treating M. catarrhalis infections.

Other names: UspA1UspA2UspA2HCopBUbiquitous Surface Proteins

Mechanism of action

N/A

Biological functions

AdhesionComplement InhibitionSerum ResistanceImmune EvasionIron AcquisitionBiofilm formationHost cell interaction

Disease associations

Otitis MediaChronic Obstructive Pulmonary Disease (COPD)Respiratory Tract InfectionsBacterial Infection

Safety considerations

Sequence diversity poses challenges for vaccine development.Potential for off-target effects if targeting highly conserved regions.Resistance development if targeting essential functions.

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