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Target intelligence / Profile preview
Moraxella catarrhalis ubiquitous surface protein A2 (UspA2)
- Target
- UspA2
- Molecular classification
- Outer membrane protein, Surface protein, Adhesin
01
Overview
UspA2 is a major outer membrane protein of Moraxella catarrhalis that contributes to serum resistance by binding to C4BP, thereby inhibiting the complement cascade. It also functions as an adhesin, binding to extracellular matrix proteins and facilitating bacterial attachment to host cells. Genetic variations and recombination events can lead to altered binding properties and enhanced immune evasion. UspA2 is a promising vaccine candidate due to its high expression and immunogenicity.
- Other names
- M. catarrhalis UspA2Branhamella catarrhalis UspA2
02
Mechanism of action
N/A (Targeted by bactericidal antibodies; potential vaccine target)
03
Biological functions
Serum resistanceComplement evasionAdhesion to host cellsExtracellular matrix bindingImmune evasion
04
Disease associations
Bacterial infectionRespiratory infectionOtitis mediaPneumoniaCOPD exacerbation
05
Safety considerations
Potential for antigenic variationNeed to elicit broadly cross-reactive antibodies for effective vaccine development
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