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Target intelligence / Profile preview
MORF4L2 antisense RNA 1 (MORF4L2-AS1)
- Target
- MORF4L2-AS1
- Molecular classification
- Antisense long noncoding RNA (lncRNA) gene, Noncoding RNA, Regulatory RNA
01
Overview
MORF4L2 antisense RNA 1 (MORF4L2-AS1) is a long noncoding RNA gene found on the positive strand of chromosome X, overlapping or in close proximity to the MORF4L2 protein-coding gene. As an antisense lncRNA, its function likely includes regulation of the MORF4L2 sense gene and possibly other nearby loci through mechanisms such as chromatin remodeling, transcriptional interference, or RNA-mediated silencing. Transcriptomic studies suggest MORF4L2-AS1 may have tissue-specific expression patterns and has been associated (by correlation) with certain diseases including glioma susceptibility and leukodystrophies, but its direct biological functions and disease relevance remain largely unexplored and unvalidated. No drugs or specific mechanisms of action targeting this lncRNA have been reported.
- Other names
- MORF4L2-AS1MORF4L2 antisense RNA 1NCBI Gene ID: 340544Ensembl: ENSG00000231154HGNC: 27991
02
Mechanism of action
Not applicable
03
Biological functions
Regulation of gene expression (potentially of MORF4L2, though direct functional studies are limited)Chromatin regulation (by analogy to other antisense lncRNAs)Possible involvement in cell type- or tissue-specific expression profiles
04
Disease associations
Linked by expression studies to Glioma Susceptibility 1 (association is expression-based, functional relevance not fully established)Linked by expression studies to Pelizaeus-Merzbacher Disease (association is expression-based, functional relevance not fully established)
05
Safety considerations
None known
06
Biomarkers
Potential biomarker status in disease association datasets, especially glioma susceptibility
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