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MORN repeat-containing protein 4 (MORN4)
- Target
- MORN4
- Molecular classification
- Other (Tandem repeat protein, protein-protein interaction module)
01
Overview
MORN repeat-containing protein 4 (MORN4) is a protein characterized by multiple MORN (Membrane Occupation and Recognition Nexus) repeats, which function as specific protein-binding modules that recognize and bind protein cargoes such as the tail of myosin 3a[1]. It forms an extended single-layered β-sheet with a U-shaped groove for high-affinity, specific binding. MORN4 is located in the cytoplasm and filopodium tip and has been implicated in promoting axonal degeneration following neuronal injury due to toxic insult or trauma[3][5][6]. Diseases associated with mutations in MORN4 include autosomal recessive nonsyndromic deafness and Deafness, Autosomal Recessive 30[3]. There is currently no evidence that MORN4 is a therapeutic target, nor are there known interacting drugs or safety concerns described.
- Other names
- MORN4MORN repeat-containing protein 4C10orf83bA548K23.4FLJ25925rtpProtein 44050Retinophilin44050 proteinretinophilin homolog (Drosophila)UTA
02
Biological functions
Promoting axonal degenerationprotein binding (especially recognizing the tail cargo binding region from Myo3a)
03
Disease associations
Deafness, Autosomal Recessive 30Autosomal Recessive Nonsyndromic Deafness
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