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MORN repeat-containing protein 5 (MORN5)
- Target
- MORN5
- Molecular classification
- Other (MORN repeat-containing protein; not classified as enzyme, receptor, ion channel, transporter, or transcription factor)
01
Overview
MORN repeat-containing protein 5 (MORN5) is a cytoplasmic protein characterized by the presence of multiple MORN (Membrane Occupation and Recognition Nexus) repeats, which are protein-protein interaction modules found across eukaryotes and prokaryotes[1][3]. MORN5 plays a role in embryonic development, particularly in craniofacial structures, where it is expressed in a highly specific spatial and temporal pattern during facial morphogenesis in vertebrates, including chick and human embryos[2]. It is regulated by and required for BMP (Bone Morphogenetic Protein) signaling, and modulates the expression of genes in both BMP and TGFβ (Transforming Growth Factor beta) pathways[2]. Variants in MORN5 have been associated with increased risk of non-syndromic cleft lip with or without cleft palate in humans, suggesting a clinically relevant developmental function[2]. To date, there is no evidence that MORN5 acts as a therapeutic target, receptor, enzyme, or has direct pharmacological modulation, and its biochemical functions remain incompletely defined[3][1][2].
- Other names
- C9orf113C9orf18FLJ46909MORN repeat-containing protein 5
02
Mechanism of action
null
03
Biological functions
Developmental processes (facial/craniofacial development[2])Potential modulation of BMP and TGFβ signaling pathways[2]Protein-protein interaction module (mediated by MORN repeats)[1]
04
Disease associations
Developmental disorder (association with risk of non-syndromic cleft lip and/or palate in humans[2])Other
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