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Mortality factor 4 (MORF4)
- Target
- MORF4
- Molecular classification
- Transcription factor, Chromatin-associated protein, Member of the MORF4 protein family
01
Overview
Mortality factor 4 (MORF4) is a gene cloned from human chromosome 4, encoding a transcriptional regulator protein with motifs such as nuclear localization signal, helix-loop-helix, and leucine zipper domains commonly seen in regulatory proteins. MORF4 induces cellular senescence, particularly in groups of immortal tumor cells, through its regulation of transcription; its protein is highly unstable and tightly controlled by ubiquitin-proteasome–mediated degradation. It is a member of a small gene family, including MRG15 and MRGX; MORF4 shares high sequence identity with these but is a truncated version. MORF4 participates in several nuclear protein complexes but is not itself a conventional therapeutic target or drug receptor.
- Other names
- Mortality factor on chromosome 4MORF4 (gene/protein)Senescence-inducing factor
02
Biological functions
Induction of cellular senescenceRegulation of transcriptionNegative regulation of cell proliferationChromatin modification (indirect, via protein complexes)
03
Disease associations
Cancer (tumor suppression through induction of senescence)Possibly neurodegenerative disease (implicated through dysregulation of protein degradation, though direct roles are less clear)
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