Mortality factor 4-like protein 2 (MORF4L2)

Mortality factor 4-like protein 2 (MORF4L2) is a nuclear protein encoded on the human X chromosome and operates as a component of the NuA4 histone acetyltransferase complex, which modulates chromatin structure and promotes transcriptional activation of select genes by mediating histone H4 and H2A acetylation[1][2][8]. These epigenetic modifications can alter nucleosome–DNA interactions and facilitate recruitment of additional proteins that regulate gene transcription. MORF4L2 is also implicated in the positive regulation of homologous recombination repair of double-strand DNA breaks and cell cycle regulation, and may contribute to complexes with both pro- and anti-transcriptional properties. Its roles intersect with those of several other chromatin regulators, and mutations or dysregulation have rare disease associations, but typically it is not a direct therapeutic or diagnostic target[1][2][8][7].

Other names

MORF4L2KIAA0026MRGXMORF-related gene X proteinProtein MSL3-2Transcription factor-like protein MRGXMORFL22410017O14RikLOC100045126Sid393pmKIAA0026LRRG00119

Not applicable, since no drugs are known to target MORF4L2 directly.