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Motile sperm domain-containing protein 3 (MOSPD3)
- Target
- MOSPD3
- Molecular classification
- Other (multi-pass membrane protein with a major sperm protein [MSP] domain)
01
Overview
Motile sperm domain-containing protein 3 (MOSPD3) is a multi-pass transmembrane protein defined by an N-terminal major sperm protein (MSP) domain and two transmembrane domains. It is highly conserved in mammals and appears to play a role in mitochondrial positioning and the organization of smooth endoplasmic reticulum structures. Studies in mice show that loss of Mospd3 causes lethal defects in right heart ventricle development, suggesting a critical role in embryonic cardiac morphogenesis and possibly in congenital heart disease. There are currently no known direct therapeutic ligands, established disease biomarkers, or notable drug safety considerations associated with this protein.
- Other names
- MOSPD3CDS3NET30motile sperm domain containing 3motile sperm domain-containing protein 3
02
Biological functions
Peripheral distribution of mitochondriaInduction of organized smooth endoplasmic reticulum (OSER) structures when overexpressedInvolved in cardiac development, specifically right ventricle morphogenesis
03
Disease associations
Heart development defects (right ventricle defects)Potential involvement in congenital heart disease
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