Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Mouse double minute X (MDMX)
- Target
- MDMX
- Molecular classification
- Transcription factor, p53 regulator
01
Overview
MDMX, also known as MDM4, is a critical negative regulator of the tumor suppressor protein p53. It inhibits p53's transcriptional activity by binding to its transactivation domain. While lacking intrinsic E3 ubiquitin ligase activity, it forms a heterodimer with MDM2 to suppress p53 activity. Overexpression of MDMX is implicated in various cancers, making it a target for therapeutic intervention aimed at restoring wild-type p53 function.
- Other names
- MDM4Double minute 4 proteinMdm2-like p53-binding proteinProtein Mdmxp53-binding protein Mdm4mdmxmdmXMdmx
02
Mechanism of action
Disrupting the MDMX-p53 interaction, blocking MDMX-MDM2 heterodimerization
03
Biological functions
Negative regulation of TP53/p73Inhibition of transcriptional activationRegulation of cell cycle arrestRegulation of apoptosis
04
Disease associations
Cancer
05
Safety considerations
Reactivation of p53 can lead to unwanted side effects
Beyond the preview
Go deeper on Mouse double minute X (MDMX).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Mouse double minute X (MDMX).