MOV10 RNA helicase (MOV10)

MOV10 RNA helicase is an evolutionarily conserved, ATP-dependent RNA helicase involved in RNA silencing and regulation of retroelements. It is a component of the RNA-induced silencing complex (RISC), where it interacts with Argonaute proteins and participates in miRNA- and siRNA-mediated mRNA degradation. MOV10 restricts retrovirus replication and inhibits retrotransposition of human genomic elements such as LINE-1, Alu, and SVA by associating with their ribonucleoprotein complexes. It also interacts with critical neuronal RNA-binding proteins, including FMRP (fragile X mental retardation protein). MOV10 is essential for early embryonic development, particularly during gastrulation and in early neural development. Phosphorylation of specific residues controls its activity, and dysregulation may contribute to neurodevelopmental disorders or increased genomic instability.

Other names

Helicase MOV-10KIAA1631gb110MGC2948fSAP113Armitage homologMoloney leukemia virus 10 proteinfunctional spliceosome-associated protein 113putative helicase MOV-10Mov10 RISC complex RNA helicase