MPN domain-containing protein (MPND)

MPN domain-containing protein (MPND) is a human protein encoded on chromosome 19, distinguished by possessing an MPN domain often linked to protein complexes that function in isopeptidase and metalloisopeptidase activities, particularly those associated with ubiquitin and protein turnover. MPND acts as a sensor of N6-methyladenosine (m6A) DNA methylation, binding selectively to m6A-modified double-stranded DNA and leading to DNA degradation. It is predicted to have protease/metallopeptidase activity and bind polyubiquitin, and may participate in DNA damage repair steps via association with the BRCA1-A and BRISC complexes. Genetic association studies implicate it in cerebellar ataxia and Machado-Joseph Disease. However, MPND is not currently classified as a direct therapeutic target; there are no drugs or clinical agents known to act on it, nor are there established biomarkers or safety concerns for therapeutic use. If a more specific molecular subclass or canonical role emerges from further research, current classification may be updated from "Other" to, for example, "Enzyme/metallopeptidase," but at present, "Other" is appropriate given the evidence.

Other names

MPNDFLJ14981ENSG00000008382MPN domain-containing protein

Not applicable (no drugs known to act on this protein)