Target intelligence / Profile preview

MPPED2 antisense RNA 1 (MPPED2-AS1)

Target: MPPED2-AS1
Molecular classification: Long non-coding RNA (lncRNA), Antisense RNA

Overview

MPPED2 antisense RNA 1 (MPPED2-AS1) is a long non-coding RNA gene located antisense to the MPPED2 gene on chromosome 11p13. It is downregulated in several cancer types and acts as an epigenetic regulator, modulating the methylation and expression of the tumor suppressor gene MPPED2 by interacting with DNA methyltransferase 1 (DNMT1). This regulatory relationship appears important for suppressing cell proliferation, migration, and invasion in cancer cells. Because MPPED2-AS1 is associated with tumor suppressor activity and downregulation in cancers, it is under investigation as a potential diagnostic and prognostic biomarker, though it is not considered a conventional therapeutic target[1][3][5].

Other names: RP5-1024C24.1

Biological functions

Epigenetic regulation of gene expression, specifically influencing the methylation status and expression of the neighboring MPPED2 geneLikely tumor suppressor role via indirect regulation of cell proliferation, migration, and invasion (mediated through MPPED2 protein levels)

Disease associations

Cancer (documented tumor suppressor–associated downregulation in breast carcinoma, papillary thyroid carcinoma, with evidence for a role in carcinogenesis)

Biomarkers

Reduced expression of MPPED2-AS1 is associated with certain cancers, such as breast and thyroid carcinomas, and may serve as a diagnostic/prognostic biomarker

Beyond the preview

Go deeper on MPPED2 antisense RNA 1 (MPPED2-AS1).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on MPPED2 antisense RNA 1 (MPPED2-AS1).

Explore the full profile