MPV17 mitochondrial inner membrane protein like 2 (MPV17L2)

MPV17L2 (MPV17 mitochondrial inner membrane protein like 2) is an integral protein of the mitochondrial inner membrane, playing a crucial role in the assembly and stability of mitochondrial ribosomes. It is essential for mitochondrial translation by associating with the large subunit of the mitochondrial ribosome and the monosome, thereby contributing to the biogenesis and function of mitochondrial ribosomes. Downregulation or loss of MPV17L2 impairs mitochondrial translation, leads to defective ribosome assembly, and disturbs mitochondrial DNA organization, resulting in morphological changes such as mitochondrial swelling and nucleoid aggregation. MPV17L2 is not known to function as a classical druggable target such as a receptor, enzyme, or transporter, nor is it a validated disease biomarker. Its main biological relevance lies in its fundamental role in mitochondrial gene expression and organelle stability, with rare associations to neurological diseases likely as part of mitochondrial dysfunction syndromes.

Other names

Mpv17-like protein 2FKSG24MGC12972mpv17-like protein 2MPV17 mitochondrial membrane protein-like 2

Not applicable (no known drugs or direct pharmacological modulation)