Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
MRE11-RAD50-NBS1 Complex (MRN)
- Target
- MRN
- Molecular classification
- Protein Complex, Nuclease, ATPase, DNA Repair Complex
01
Overview
The MRE11-RAD50-NBS1 (MRN) complex is a highly conserved, multi-protein assembly essential for the detection and repair of DNA double-strand breaks (DSBs). The MRN complex plays central roles in sensing DSBs, processing DNA ends for repair, activating cell cycle checkpoint signaling via ATM/ATR kinases, and tethering and bridging broken DNA ends to facilitate accurate repair. It is comprised of the MRE11 nuclease, the RAD50 ATPase, and the NBS1 regulatory subunit. Mutations in MRN components are associated with severe genomic instability syndromes.
02
Mechanism of action
Not applicable, as MRN is a complex, not a single druggable target. Interventions would likely target individual components or downstream pathways.
03
Biological functions
DNA double-strand break repairCheckpoint signalingHomologous recombinationGenome stabilityDNA end processingATM/ATR kinase activationDNA tethering
04
Disease associations
Ataxia-Telangiectasia-Like Disorder (ATLD)Nijmegen Breakage SyndromeCancer predispositionImmunodeficiency
05
Safety considerations
Potential for off-target effects on DNA repair pathwaysGenomic instability if repair is improperly inhibitedComplex role in tumor suppression vs. tumor promotion depending on context
06
Biomarkers
MRE11 expression levelsNBS1 expression levelsATM/ATR phosphorylation statusγ-H2AX levels
Beyond the preview
Go deeper on MRE11-RAD50-NBS1 Complex (MRN).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on MRE11-RAD50-NBS1 Complex (MRN).