mRNA stabilization

mRNA stabilization is not a single molecule or receptor but a complex, essential cellular process regulating the lifespan and availability of messenger RNAs, ultimately impacting protein production. Mechanisms controlling mRNA stability include the action of RNA-binding proteins that bind cis-regulatory elements (such as AU-rich elements) within the mRNA, chemical modifications like methylation (e.g., m^7G cap, m^6Am, m^5C, pseudouridine) that enhance mRNA integrity, and sequestration of mRNA within intracellular structures like stress granules[2][3][4][5]. Dysregulated mRNA stability is implicated in various diseases because it can alter protein expression profiles, affecting processes such as stress response, proliferation, and apoptosis[1][4][6]. However, "mRNA stabilization" is not a concrete canonical drug target but rather a regulatory process manipulated by numerous trans-acting factors and pathways.

Other names

mRNA stabilitymessenger RNA stabilizationRNA stabilization

Stabilization of mRNA via RNA-binding proteins; Chemical modification of RNA (e.g., methylation, pseudouridylation); Inhibition of mRNA degradation enzymes