mRNA targets of Bone Marrow Mesenchymal Stem Cell-derived Microvesicle (BMSC-MV) microRNA cargo

The mRNA targets of Bone Marrow Mesenchymal Stem Cell-derived Microvesicle (BMSC-MV) microRNA cargo represent a diverse set of transcripts regulated by the paracrine activity of stem cells. BMSCs secrete microvesicles that encapsulate a specific profile of microRNAs (miRNAs), which are then delivered to target cells to modulate their biological response (Source: PMC5835590). Upon entry into recipient cells, these miRNAs typically bind to the 3' untranslated regions (UTRs) of specific mRNAs, leading to gene silencing through mRNA degradation or translational inhibition (Source: Nature Reviews Genetics, 2018). This regulatory axis is a primary mechanism by which BMSC-based therapies exert anti-inflammatory, anti-apoptotic, and pro-regenerative effects in diseases such as myocardial infarction, acute kidney injury, and various cancers (Source: Stem Cell Research & Therapy, 2020). Because the term refers to a variable collection of downstream effectors rather than a single protein or nucleic acid sequence, it is characterized as a functional category of targets rather than a discrete therapeutic target. The therapeutic utility of this axis depends on the specific miRNA-mRNA interactions, which are being explored for their potential in precision regenerative medicine.

Other names

BMSC-MV miRNA targetsBMSC-EV miRNA targetsDownstream mRNA targets of BMSC-derived microvesiclesBMSC-MV miRNA-regulated genes

MicroRNAs within the microvesicles bind to the 3' untranslated regions (UTRs) of target mRNAs, leading to mRNA cleavage, destabilization, or inhibition of translation via the RNA-induced silencing complex (RISC).