MROH7-TTC4 readthrough RNA (NMD candidate) (MROH7-TTC4)

MROH7-TTC4 readthrough is a non-coding RNA gene resulting from a natural transcriptional readthrough event between the MROH7 and TTC4 loci on chromosome 1. This RNA is subject to alternative splicing, producing several transcript variants that are generally candidates for nonsense-mediated mRNA decay and are therefore unlikely to encode for a protein[1][2]. Functional annotation is limited, with minimal evidence for a direct biological role. The locus has been referenced in research examining vascular endothelial cell autophagy: specifically, regulation of its expression by upstream proteins (such as annexin A7) may indirectly influence processes like apoptosis in vascular endothelial cells, but its own mechanistic contribution remains unclear[3]. Currently, MROH7-TTC4 is not considered a druggable therapeutic target, a receptor, enzyme, or member of classical protein families. No disease associations, biomarkers, or drug interactions are reported.

Other names

C1orf175HEATR8HEATR8-TTC4Maestro heat-like repeat-containing protein family member 7MROH7HEATR8-TTC4 readthroughMROH7-TTC4 readthrough