Msh homeobox 2 pseudogene 1 (MSX2P1)

Msh homeobox 2 pseudogene 1 (MSX2P1) is a human pseudogene located at chromosome 17q23.2. It arose via retrotransposition of MSX2 mRNA and shares high sequence identity with MSX2 but lacks introns and protein-coding capacity. The locus contains remnants of a poly(A) tail, and like other pseudogenes, it is not thought to encode functional proteins. In some contexts, non-coding RNAs from MSX2P1 have been implicated in aberrant cellular proliferation, but there is no evidence for its direct involvement in human disease as a classical gene or pharmacological target. Key distinction: MSX2P1 is sometimes confused with MSX2, a homeobox transcription factor important in craniofacial development and several disease states. Only MSX2—not MSX2P1—is a conventional molecular target with protein-coding function. Summary: MSX2P1 should not be considered a drug target, receptor, or functional entity in the conventional sense. Its aliases and history reflect database entries for non-coding or retroposed loci, not for a canonical protein or molecular target.

Other names

HSHPX5HPX5MSX2Pmsh homeobox 2 pseudogene 1

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