MT-CO1 pseudogene 23 (MTCO1P23)

MT-CO1 pseudogene 23 (MTCO1P23) is a pseudogene identified in genomic databases (e.g., NCBI Gene accession 107075281, Ensembl ENSG00000235524)[2]. Pseudogenes are genomic sequences that are homologous to known genes but are generally nonfunctional due to accumulated mutations and lack of expression or protein-coding capacity. MTCO1P23 resembles the functional mitochondrial gene MT-CO1, which encodes cytochrome c oxidase I (a critical subunit of the mitochondrial respiratory chain complex IV)[1][3]. However, unlike MT-CO1, the pseudogene version MTCO1P23 does not encode a functional protein and is not involved in cellular respiration or any known biological process. MT-CO1 itself is a major component of mitochondrial oxidative phosphorylation and has clinical significance in mitochondrial diseases[1][3][5]. In contrast, pseudogenes such as MTCO1P23 are mainly of interest for evolutionary studies or as a tool for genetic sequence identification and do not have therapeutic, biomarker, or direct disease relevance. Key distinctions from related targets: - The functional gene (MT-CO1, COX1) is essential for energy production and associated with various diseases[1][3][5]. - MTCO1P23 is a non-coding pseudogene and is not considered a protein target or involved in any drug interactions, disease mechanisms, or therapeutic pathways[2].

Other names

mitochondrially encoded cytochrome c oxidase I pseudogene 23MTCO1P23