MT-CO1 pseudogene 6 (MTCO1P6)

MT-CO1 pseudogene 6 (MTCO1P6) belongs to a class of mitochondrial pseudogenes found in the human genome. Unlike the true MT-CO1 gene—which encodes cytochrome c oxidase I, a critical subunit of Complex IV in the mitochondrial electron transport chain—MTCO1P6 is classified as a pseudogene and does not produce a functional protein. Pseudogenes traditionally arise from duplication or retrotransposition events and generally lack biological activity—they are not transcribed or translated into functional products, nor are they typical targets in drug development or disease biology[3]. MTCO1P6 is an approved locus by the HUGO Gene Nomenclature Committee and is distinct from the functional mitochondrial gene MT-CO1, which has known pathological and biomarker roles, but MTCO1P6 itself does not share these properties[1][3]. MTCO1P6 should not be confused with MT-CO1 (COX1), which does encode an enzymatic protein pivotal for cellular respiration and disease processes such as complex IV deficiency, Leber's hereditary optic neuropathy, and more[1][4]. The pseudogene MTCO1P6 has no direct biological function or disease association and is not considered a therapeutic target.

Other names

MTCO1P6MT-CO1P6mitochondrial cytochrome c oxidase I pseudogene 6