MT-CO2 pseudogene 9 (MTCO2P9)

MTCO2P9 is a pseudogene derived from the mitochondrial MT-CO2 gene, which encodes cytochrome c oxidase subunit II. Pseudogenes are DNA sequences that have lost their protein-coding ability through evolution, typically due to mutations that disrupt their normal function[5]. While the parent gene MT-CO2 is essential for mitochondrial electron transport and ATP synthesis as part of complex IV of the respiratory chain[1][4], MTCO2P9 itself is non-coding and does not produce a functional protein. Mitochondrial pseudogenes like MTCO2P9 represent sequences of mitochondrial DNA that have been incorporated into the nuclear genome but are themselves noncoding[5]. Unlike its functional counterpart MT-CO2, which plays a crucial role in cellular energy metabolism and is associated with various mitochondrial diseases[4], MTCO2P9 serves no known biological function and is not considered a therapeutic target. The pseudogene is cataloged in genomic databases with the accession numbers 107075267 (NCBI Gene) and ENSG00000249386 (Ensembl)[3][8].

Other names

MT-CO2 pseudogene 9mitochondrially encoded cytochrome c oxidase II pseudogene 9

Not applicable