MT-CO3 pseudogene 2 (MTCO3P2)

MT-CO3 pseudogene 2 (MTCO3P2) is a human pseudogene annotated as a non-functional genomic sequence with sequence similarity to the functional MT-CO3 gene, which encodes the mitochondrially encoded cytochrome c oxidase III protein—an essential component of complex IV in the mitochondrial respiratory chain. Pseudogenes, such as MTCO3P2, do not produce a functional protein product and are not considered therapeutic targets, nor are they involved in canonical biological, disease, or drug interaction pathways. The designation “pseudogene” indicates that while it shares sequence homology with a functional gene (in this case, the mitochondrial gene MT-CO3), it has lost the capacity for protein coding due to mutations or the absence of regulatory elements necessary for expression. MTCO3P2 should not be confused with MT-CO3, the coding gene for cytochrome c oxidase subunit III, mutations of which are associated with mitochondrial diseases such as Leigh syndrome and mitochondrial complex IV deficiency.

Other names

MTCO3 pseudogene 2mitochondrially encoded cytochrome c oxidase III pseudogene 2

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