MT-CYB pseudogene 28 (MTCYBP28)

**MT-CYB pseudogene 28 (MTCYBP28)** is classified as a pseudogene derived from the mitochondrially encoded cytochrome b gene. It is located on human chromosome 16 and is not believed to encode a functional protein or to have a biological function similar to the active MT-CYB gene in mitochondrial DNA. As a pseudogene, MTCYBP28 does not function as a receptor, enzyme, transporter, or therapeutic target. There is no evidence supporting any disease associations, drug interactions, or biomarker utility for this locus. Its principal relevance is as a genomic relic or sequence similarity to the functional MT-CYB gene, rather than as an active molecule with physiological or pathological roles[2][4][9][10].\n\n**Key clarifications:**\n- The functional gene MT-CYB encodes cytochrome b, an essential component of mitochondrial complex III, with roles in oxidative phosphorylation and several mitochondrial disorders[1][3][5][7]. This refers to the active mitochondrial gene, not the pseudogene.\n- MTCYBP28 is explicitly annotated as a *pseudogene* in multiple reputable databases and does not encode a protein product[2][4][9][10].\n- As a pseudogene, it is not considered a drug target or molecular entity of therapeutic relevance.\n\n**Errors and limitations:**\n- If queried as a therapeutic target, MTCYBP28 is incorrect. Only the active MT-CYB gene is relevant to mitochondrial biology and disease.\n- There can be confusion between pseudogenes like MTCYBP28 and their functional counterparts, but only the mitochondrial MT-CYB is biologically active.

Other names

MT-CYB Pseudogene 28mitochondrially encoded cytochrome b pseudogene 28MTCYBP28