MT-ND1 pseudogene 10 (MTND1P10)

MT-ND1 pseudogene 10 (MTND1P10) is a nuclear-encoded pseudogene derived from the mitochondrial MT-ND1 gene, which encodes NADH-ubiquinone oxidoreductase chain 1 (a core subunit of Complex I in the mitochondrial electron transport chain). Unlike the functional MT-ND1 gene, this pseudogene does not code for a protein and has no enzymatic or receptor activity. MTND1P10 is representative of nuclear mitochondrial pseudogenes (numts) that are remnants of historical mitochondrial DNA insertions into the nuclear genome, and current evidence does not support a direct biological or therapeutic role for MTND1P10. The majority of scientific and medical interest focuses on the functional MT-ND1 gene, whose mutations are associated with mitochondrial disorders such as Leber hereditary optic neuropathy and Leigh syndrome.

Other names

MTND1P10