MT-ND1 pseudogene 14 (MTND1P14)

MT-ND1 pseudogene 14 (MTND1P14) is a **pseudogene** found on human chromosome 17[2][4]. It is a nuclear DNA sequence with significant sequence homology to the mitochondrial gene MT-ND1, which itself encodes a core subunit of mitochondrial complex I (NADH:ubiquinone oxidoreductase)[2][4]. Unlike the genuine mitochondrial MT-ND1 gene, MTND1P14 does not produce a functional protein and currently has no known biological or disease-modifying function. It is not a protein-coding gene and therefore not a direct target for therapeutic drugs, not involved in classical molecular pathways, and not considered a biomarker or safety concern. Important clarification: There is nothing inherently "incorrect" about the gene itself, but for the purposes of drug discovery, molecular pharmacology, or biomarker research, a pseudogene like MT-ND1 pseudogene 14 is **not a suitable or recognized therapeutic target**[4]. Most research and therapeutic attention relate to the protein-coding mitochondrial gene MT-ND1; the pseudogene should not be confused with the active mitochondrial gene, which is well-known for its role in electron transfer and mitochondrial diseases[1][3][5][7]. If your query concerns the **functional protein-coding mitochondrial gene** (MT-ND1) and its core subunit, those details are available and include involvement in mitochondrial electron transport, roles in neurodegenerative and metabolic diseases, and established use as a biomarker; but these features **do not apply to the pseudogene** MTND1P14[2][4].

Other names

MTND1P14mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 pseudogene 14