MT-ND3 pseudogene 1 (MTND3P1)

MT-ND3 pseudogene 1 (MTND3P1) refers to a non-functional, non-protein-coding segment of nuclear or mitochondrial DNA that resembles the protein-coding gene MT-ND3 but does not produce a functional protein. While the functional MT-ND3 gene encodes a core subunit of mitochondrial respiratory chain complex I critical for electron transport and ATP production[1][2][3], the pseudogene MTND3P1 does not encode an active protein, is not part of the electron transport chain, and has no confirmed biological or disease role. MTND3P1 is *not* a drug target, receptor, enzyme, or transporter[1][3]. Its presence in gene catalogs is for genomic reference and should not be mistaken for the protein-coding MT-ND3 subunit, which is implicated in mitochondrial disorders such as Leigh syndrome and Leber hereditary optic neuropathy[1][2][3]. Summary of key distinctions: - MTND3P1 is a **pseudogene**, so it is not a functional, therapeutic, or druggable target and should not be reported as one. - The functional target associated with mitochondrial complex I and disease is **MT-ND3 (NADH dehydrogenase 3)**, not its pseudogene. If a therapeutic target is required, use the canonical name "NADH dehydrogenase [ubiquinone] 3, mitochondrial" (MT-ND3), not the pseudogene. MTND3P1 should not be used as a therapeutic target entry.

Other names

MTND3P1MTND3 pseudogene 1mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 pseudogene 1