MT-ND3 pseudogene 3 (MTND3P3)

MT-ND3 pseudogene 3 (MTND3P3) is a pseudogene in the human genome structurally related to the functional mitochondrial MT-ND3 gene, which encodes one of the core subunits of mitochondrial NADH:ubiquinone oxidoreductase (Complex I). Unlike its protein-coding counterpart, MTND3P3 does not encode a protein, does not function as a receptor, enzyme, or therapeutic target, and does not participate in cellular electron transport or mitochondrial disease. Pseudogenes such as MTND3P3 are generally considered non-functional remnants of genes and are not included in lists of actionable therapeutic targets[5][6].\nKey clarifications:\n- MT-ND3 (without the pseudogene suffix) is a protein-coding mitochondrial gene with clinical importance in mitochondrial diseases[1][2][3][4].\n- MTND3P3 is its human pseudogene variant, lacking protein product and therapeutic relevance.\nThere is no evidence of clinical targeting, drug interaction, or biomarker use for MTND3P3. It should not be confused with the functional MT-ND3 protein.

Other names

MT-ND3 Pseudogene 3MTND3P3