MT-ND4 pseudogene 14 (MTND4P14)

MT-ND4 pseudogene 14 (MTND4P14) is a nuclear-encoded pseudogene related to the mitochondrial gene MT-ND4, which encodes an essential subunit of respiratory chain complex I (NADH:ubiquinone oxidoreductase) in mitochondria[5]. Pseudogenes like MTND4P14 are sequences that share similarity with functional genes (in this case, MT-ND4) but have acquired mutations—such as insertions, deletions, or premature stop codons—that prevent them from producing functional proteins[5]. Unlike the functional MT-ND4 gene found in mitochondrial DNA, which is implicated in mitochondrial disorders and plays a role in oxidative phosphorylation[2][3][4], its nuclear pseudogenes are considered noncoding, are not directly involved in electron transport or cellular energy production, and are not known to be therapeutic targets. Detection of pseudogene sequences may complicate genetic assays but does not confer a functional or therapeutic role. Key caveats and correction: - *MT-ND4 pseudogene 14* is **not** the same as the functional MT-ND4 gene or protein and should not be confused with the active enzyme subunit involved in electron transport and human disease. - The term “target” typically applies only to functionally expressed gene products such as enzymes, receptors, or transporters. Pseudogenes do not fit this definition[5]. - There are no clinical, diagnostic, or pharmacological activities or interactions known for MTND4P14. If a database lists it as a target, this likely results from confusion with the functional *MT-ND4* gene/protein. If you are seeking information about the **functional mitochondrial MT-ND4 gene**, which is a subunit of complex I and associated with diseases such as Leber hereditary optic neuropathy and Leigh syndrome, refer to the gene *MT-ND4* (not the pseudogene)[1][2][3][4][5]. There is no evidence in the scientific literature that MT-ND4 pseudogene 14 has a protein product, functional role, or therapeutic applications[5].

Other names

MTND4P14MT-ND4P14Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 pseudogene 14NADH dehydrogenase 4 pseudogene 14