MT-ND4 pseudogene 32 (MTND4P32)

MT-ND4 pseudogene 32 (MTND4P32) is a putative human pseudogene related in sequence to the mitochondrial gene MT-ND4, which encodes a core subunit of mitochondrial complex I (NADH:ubiquinone oxidoreductase). Unlike the functional MT-ND4 gene, pseudogenes such as MTND4P32 are traditionally considered non-functional genomic elements that no longer produce functional proteins. Some pseudogenes can be transcribed into non-coding RNA and, in certain cases, act as molecular regulators (for example, as miRNA sponges), but there is no direct evidence that MTND4P32 plays a functional or disease-related biological role. Important note: This entry should not be conflated with the functional mitochondrial gene MT-ND4, which is a core enzyme subunit involved in electron transport, and is implicated in various diseases including Leber’s hereditary optic neuropathy and others. MTND4P32, as a pseudogene, is not therapeutically actionable, does not encode a protein, and is not a recognized drug target.

None (not a target for drugs)