MT-ND5 pseudogene 23 (MTND5P23)

MT-ND5 pseudogene 23 (MTND5P23) is a pseudogene in the human genome, officially listed by the HUGO Gene Nomenclature Committee (HGNC). Pseudogenes are defective copies of functional genes that have lost their protein-coding potential due to mutations; as such, they do not encode functional proteins or act as therapeutic targets. MTND5P23 is not a mitochondrial DNA gene involved in the electron transport chain but is instead named for its resemblance to MT-ND5, a gene encoding a core subunit of mitochondrial complex I. There is no evidence that MTND5P23 has a current biological function or disease association, nor is it known to interact with any drugs or serve as a biomarker. Key context and clarifications: - MTND5P23 is a nuclear pseudogene and not an active mitochondrial gene or protein target. - The functional gene, MT-ND5 (not MTND5P23), encodes core subunit 5 of NADH:ubiquinone oxidoreductase (complex I) and is implicated in mitochondrial diseases. - MTND5P23 lacks coding potential, protein product, and does not participate in mitochondrial electron transport or any known cellular process. - Pseudogenes like MTND5P23 are not considered valid drug targets and have no recognized clinical relevance at present. Notes on possible confusion: Some resources may list pseudogenes like MTND5P23 in gene catalogs or differential expression studies, but this does not confer therapeutic target status or biological function. If your intent is to refer to the functional mitochondrial ND5 gene, use “MT-ND5” instead, which is involved in energy metabolism and several inherited diseases. For MTND5P23, the entry is correctly classified as a non-target pseudogene, and attempts to map it to a therapeutic target or molecular mechanism are not substantiated by current knowledge.

Other names

MT-ND5 pseudogene 23MTND5P23mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 pseudogene 23