MT-ND5 pseudogene 24 (MTND5P24)

MT-ND5 pseudogene 24 is a human nuclear pseudogene derived from mitochondrial DNA, representing a non-functional copy of the MT-ND5 gene. MT-ND5 itself encodes a core subunit of mitochondrial complex I (NADH:ubiquinone oxidoreductase) that is crucial for electron transport and ATP synthesis through oxidative phosphorylation[1][3][5][6][7][8]. However, MTND5P24 does not encode a functional protein product; it carries mutations and disruptions that prevent translation into a functional subunit[6]. The designation "pseudogene" indicates the sequence is a genomic relic and not an active molecular target for therapeutics or drug interactions. Variants of the functional MT-ND5 gene are associated with mitochondrial diseases, but the pseudogene MTND5P24 has no established biological or disease function. The name "MT-ND5 pseudogene 24" refers to a nuclear pseudogene, not the active mitochondrial MT-ND5 gene or protein. The active MT-ND5 gene (not the pseudogene) is involved in mitochondrial electron transport, and mutations in the authentic gene are linked to diseases like Leigh syndrome, MELAS, and Leber hereditary optic neuropathy[1][3][5][8]. The pseudogene, however, has no such roles. The query is thus focused on a non-target, and this should be flagged as potentially incorrect for pharmacological or therapeutic target inquiry. MTND5P24 is a non-functional pseudogene, not a valid drug or therapeutic target[6].

Other names

MTND5P24Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 pseudogene 24