MT-ND5 pseudogene 25 (MTND5P25)

MT-ND5 pseudogene 25 (MTND5P25) is a nuclear sequence derived from the mitochondrial gene that encodes NADH:ubiquinone oxidoreductase core subunit 5, a protein involved in the mitochondrial respiratory chain complex I[2][4][5]. Unlike the functional mitochondrial ND5 gene, MTND5P25 contains numerous mutations (e.g., frameshifts and premature stop codons)[5] and does not encode a functional protein. Such pseudogenes are created via transfer of mitochondrial DNA fragments to the nucleus and can be detected by PCR, but do not contribute to cellular metabolism or disease directly. They are not considered valid drug targets or biomarkers in current biomedical research[5].\n\nIf you require information about the active mitochondrial ND5 gene (rather than the pseudogene), it is a core subunit of respiratory chain complex I with established biological and disease relevance[1][6].

Other names

MTND5P25mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 pseudogene 25MT-ND5 pseudogene 25