MT-ND6 pseudogene 11 (MTND6P11)

MT-ND6 pseudogene 11 is classified as a pseudogene related to the mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 (MT-ND6) gene. Pseudogenes are DNA sequences similar to known genes but non-functional, typically due to mutations or lack of regulatory elements. MTND6P11 does not encode a protein product, play a role in oxidative phosphorylation, or participate in mitochondrial respiratory function. All functional and disease-relevant roles are attributed to the MT-ND6 gene, not this pseudogene[1][2]. The confusion may arise from conflation of MTND6P11 with the functional MT-ND6 gene, which is a protein-coding gene vital for mitochondrial electron transport and ATP generation, and is associated with certain mitochondrial diseases such as Leber hereditary optic neuropathy and Leigh syndrome[1][2]. MTND6P11 has no known functional or therapeutic relevance.

Other names

MTND6P11MTND6 pseudogene 11mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 pseudogene 11

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