MT-ND6 pseudogene 2 (MTND6P2)

MT-ND6 pseudogene 2 (MTND6P2) is a pseudogene related to the mitochondrial gene MT-ND6, which encodes NADH dehydrogenase subunit 6. While the parent gene MT-ND6 is a crucial component of Complex I in the mitochondrial electron transport chain[1][2], pseudogenes like MTND6P2 are non-functional gene copies that have lost their protein-coding capacity through evolutionary processes. The search results mention that several MT-ND6 pseudogenes exist, including MTND6P3, which has been found to be differentially expressed in Alzheimer's disease patients[4]. However, specific information about MTND6P2's function, expression patterns, or clinical significance is not available in the current search results. Pseudogenes were traditionally considered "junk DNA," but recent research suggests some may have regulatory functions, though this has not been established for MTND6P2 specifically. The parent gene MT-ND6 is located on the L-strand of human mitochondrial DNA and encodes a 172-amino acid protein that is essential for Complex I function in cellular respiration[1][2]. Mutations in MT-ND6 are associated with various mitochondrial diseases including Leigh syndrome and Leber hereditary optic neuropathy[1][3].

Other names

MTND6 pseudogene 2mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 pseudogene 2