MT-ND6 pseudogene 21 (MTND6P21)

MT-ND6 pseudogene 21 (MTND6P21) is a nuclear-encoded pseudogene related to the mitochondrial ND6 gene, which normally codes for the ND6 subunit of complex I in the mitochondrial respiratory chain. Unlike the protein-coding ND6 gene—which plays a vital role in mitochondrial energy metabolism and is implicated in diseases such as Leber hereditary optic neuropathy and Leigh syndrome[1][2][5]—MTND6P21 is a non-coding pseudogene, and evidence for its functional biological role or association with human disease is highly limited. Some studies suggest possible expression changes in mitochondrial pseudogenes and isoforms in neurodegenerative diseases, but these links remain unconfirmed and preliminary[4]. There are no known drugs, mechanisms, biomarkers, or safety concerns directly related to MTND6P21. *Note: If a functional target related to the ND6 subunit is required, refer to the canonical mitochondrial ND6 gene (MT-ND6), not MT-ND6 pseudogene 21.*

Other names

MTND6 pseudogene 21mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 pseudogene 21MTND6P21